A Boron-10 nitride nanosheet for combinational boron neutron capture therapy and chemotherapy of tumor

Combination cancer therapy (e.g., radiochemotherapy) is widely used to enhance the therapeutic effects and prevent recurrence of cancer. However, side monotherapy are also amplified when treating with combination therapy. A locally activated drug delivery strategy that can release payload in a tumor-selective manner greatly needed overcome Here, we explore potential combining boron neutron capture chemotherapy as new type radiochemotherapy. Two-dimensional (2D) boron-10-rich nanosheets (BNNSs) were fabricated dual-functional system: targeted boron-10 systems for (BNCT) vehicles load doxorubicin chemotherapy. Irradiated by low-energy thermal neutron, BNNSs produce high linear energy transfer (LET) particles kill tumor cells, loaded be released situ at same time. This neutron-triggered radiochemotherapy shows noteworthy efficacy suppressing growth triple-negative breast To best our knowledge, this first report combine BNCT We hope study could inspire additional BNCT-induced therapies provide insight further clinical translation BNCT.